Treatments for Major Depression In addition to psychotherapy and medication management for depression, recent years have seen the development of two promising and very well tolerated therapies, transcranial magnetic stimulation (TMS) and ketamine. Transcranial Magnetic Stimulation TMS is the use of a figure of eight magnetic coil that is positioned on the scalp in a precise location known to be involved in regulating mood state. This part of the brain is known at the dorsola